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TargetSerotonin 1B/1D receptor
LigandBDBM50086096
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1774
IC50 2.1±n/a nM
Citation Matzen, Lvan Amsterdam, CRautenberg, WGreiner, HEHarting, JSeyfried, CABöttcher, H 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants. J Med Chem43:1149-57 (2000) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serotonin 1B/1D receptor
Name:Serotonin 1B/1D receptor
Synonyms:5-HT-1B | 5-HT1B | 5-hydroxytryptamine receptor 1B (5HT1B) | Serotonin 1 (5-HT1) receptor | Serotonin receptor 1B
Type:Protein
Mol. Mass.:43173.33
Organism:Rattus norvegicus (Rat)
Description:P28564
Residue:386
Sequence:
MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATT
LSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDF
WLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPP
FFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTP
NKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKL
MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLI
NPIIYTMSNEDFKQAFHKLIRFKCTG
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  Blast E-value cutoff:
BDBM50086096
NameBDBM50086096
Synonyms:2'-Methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxylic acid [2,3-Dihydro-1'-methylspiro(benzofuran-3,4'-piperidine)]-amide | CHEMBL15933 | N-(2,3-Dihydro-1'-methylspiro[benzofuran-3,4'-piperidine]-5-yl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenylcarboxamide
TypeSmall organic molecule
Emp. Form.C30H30N4O3
Mol. Mass.494.5842
SMILESCN1CCC2(COc3ccc(NC(=O)c4ccc(cc4)-c4ccc(cc4C)-c4noc(C)n4)cc23)CC1
Structure
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n/a