Reaction Details Report a problem with these data
Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM50086578
Substrate
n/a
Meas. Tech.
ChEBML_67532
Ki
>100000±n/a nM
Citation
 Hanessian, S; Sgarbi, PW Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases. Bioorg Med Chem Lett 10:433-7 (2000) [PubMed]  Article 
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
ERM_STREE | ErmAM | Macrolide-lincosamide-streptogramin B resistance protein | erm
Type:
PROTEIN
Mol. Mass.:
28804.82
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_67532
Residue:
245
Sequence:
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNIRVTLIHQDILQFQFPNKQRYKIVGSIPYHLSTQIIKKVVFESHASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLLFNGRK
  
Inhibitor
Name:
BDBM50086578
Synonyms:
(1R,2S,3R,5S)-5-[4-Amino-6-(indan-2-ylamino)-[1,3,5]triazin-2-yl]-3-benzyloxy-cyclohexane-1,2-diol | CHEMBL342405
Type:
Small organic molecule
Emp. Form.:
C25H29N5O3
Mol. Mass.:
447.5295
SMILES:
Nc1nc(NC2Cc3ccccc3C2)nc(n1)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C1)OCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: