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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50086966
Substrate
n/a
Meas. Tech.
ChEMBL_161563 (CHEMBL768926)
IC50
1300±n/a nM
Citation
 Malamas, MS; Sredy, J; Moxham, C; Katz, A; Xu, W; McDevitt, R; Adebayo, FO; Sawicki, DR; Seestaller, L; Sullivan, D; Taylor, JR Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties. J Med Chem 43:1293-310 (2001) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50086966
Synonyms:
CHEMBL282855 | {1-Bromo-6-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-naphthalen-2-yloxy}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C23H15BrF3NO4
Mol. Mass.:
506.269
SMILES:
Cc1oc(nc1-c1ccc2c(Br)c(OCC(O)=O)ccc2c1)-c1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: