Reaction Details Report a problem with these data
Target
Beta-1 adrenergic receptor
Ligand
BDBM50087520
Substrate
n/a
Meas. Tech.
ChEMBL_37540 (CHEMBL647622)
Ki
560.0±n/a nM
Citation
 Lu, SF; Herbert, B; Haufe, G; Laue, KW; Padgett, WL; Oshunleti, O; Daly, JW; Kirk, KL Syntheses of (R)- and (S)-2- and 6-fluoronorepinephrine and (R)- and (S)-2- and 6-fluoroepinephrine: effect of stereochemistry on fluorine-induced adrenergic selectivities. J Med Chem 43:1611-9 (2000) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1R, B1AR | ADRB1_RAT | Adrb1 | Adrb1r | Adrenergic receptor beta | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 | adrenergic Beta1,2
Type:
Protein
Mol. Mass.:
50486.84
Organism:
Rattus norvegicus (Rat)
Description:
P18090
Residue:
466
Sequence:
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
  
Inhibitor
Name:
BDBM50087520
Synonyms:
(R)3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol | CHEMBL42370
Type:
Small organic molecule
Emp. Form.:
C9H12FNO3
Mol. Mass.:
201.1949
SMILES:
CNC[C@H](O)c1ccc(O)c(O)c1F
Structure:
Search PDB for entries with ligand similarity: