Reaction Details Report a problem with these data
Target
4-hydroxyphenylpyruvate dioxygenase
Ligand
BDBM50088803
Substrate
n/a
Meas. Tech.
ChEMBL_547 (CHEMBL615567)
IC50
500±n/a nM
Citation
 Lin, YL; Wu, CS; Lin, SW; Yang, DY SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett 10:843-5 (2000) [PubMed]  Article 
Target
Name:
4-hydroxyphenylpyruvate dioxygenase
Synonyms:
HPD | HPPD_PIG
Type:
PROTEIN
Mol. Mass.:
45064.25
Organism:
Sus scrofa
Description:
ChEMBL_541
Residue:
393
Sequence:
MTSYSDKGEKPERGRFLHFHSVTFWVGNAKQAASYYCSKIGFEPLAYKGLETGSREVVSHVVKQDKIVFVFSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAIIVREEVCCAADVRGHHTPLDRARQVWEGTLVEKMTFCLDSRPQPSQTLLHRLLLSKLPKCGLEIIDHIVGNQPDQEMESASQWYMRNLQFHRFWSVDDTQIHTEYSALRSVVMANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRSLRERGVEFLAVPFTYYKQLQEKLKSAKIRVKESIDVLEELKILVDYDEKGYLLQIFTKPMQDRPTVFLEVIQRNNHQGFGAGNFNSLFKAFEEEQELRGNLTDTDPNGVPFRL
  
Inhibitor
Name:
BDBM50088803
Synonyms:
2-(2-Chloro-benzoyl)-cyclohexane-1,3-dione | CHEMBL166951 | CHEMBL72258
Type:
Small organic molecule
Emp. Form.:
C13H11ClO3
Mol. Mass.:
250.678
SMILES:
Clc1ccccc1C(=O)C1C(=O)CCCC1=O
Structure:
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