Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50088811
Substrate
n/a
Meas. Tech.
ChEBML_47848
IC50
36800±n/a nM
Citation
 Buynak, JD; Doppalapudi, VR; Rao, AS; Nidamarthy, SD; Adam, G The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. Bioorg Med Chem Lett 10:847-51 (2000) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase class C
Type:
PROTEIN
Mol. Mass.:
41618.07
Organism:
Enterobacter cloacae
Description:
ChEMBL_47855
Residue:
384
Sequence:
MMKKSLCCALLLGISCSALATPVSEKQLAEVVANTVTPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50088811
Synonyms:
CHEMBL166677 | [(R)-2-Carboxy-3-methyl-4-methylene-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-en-(7Z)-ylidene]-acetic acid anion; Disodium
Type:
Small organic molecule
Emp. Form.:
C11H7NO7S
Mol. Mass.:
297.242
SMILES:
CC1=C(N2[C@@H](\C(=C/C([O-])=O)C2=O)S(=O)(=O)C1=C)C([O-])=O |t:1|
Structure:
Search PDB for entries with ligand similarity: