Reaction Details Report a problem with these data
Target
Tissue-type plasminogen activator
Ligand
BDBM50088984
Substrate
n/a
Meas. Tech.
ChEBML_207872
IC50
>2500±n/a nM
Citation
Tamura, SY; Weinhouse, MI; Roberts, CA; Goldman, EA; Masukawa, K; Anderson, SM; Cohen, CR; Bradbury, AE; Bernardino, VT; Dixon, SA; Ma, MG; Nolan, TG; Brunck, TK Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors. Bioorg Med Chem Lett 10:983-7 (2000) [PubMed] Article
More Info.:
Target
Name:
Tissue-type plasminogen activator
Synonyms:
Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator
Type:
Enzyme
Mol. Mass.:
62931.08
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
562
Sequence:
MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
Inhibitor
Name:
BDBM50088984
Synonyms:
2-Benzenesulfonylamino-N-[1-(1-carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-ethyl]-3-hydroxy-propionamide; TFA | CHEMBL366964
Type:
Small organic molecule
Emp. Form.:
C18H28N6O6S
Mol. Mass.:
456.517
SMILES:
C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N