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Target
Bombesin receptor subtype-3
Ligand
BDBM50533327
Substrate
n/a
Meas. Tech.
ChEMBL_1925031 (CHEMBL4427987)
EC50
1.000000±n/a nM
Citation
 Kiyotsuka, Y; Shimada, K; Kobayashi, S; Suzuki, M; Akiu, M; Asano, M; Sogawa, Y; Hara, T; Konishi, M; Abe-Ohya, R; Izumi, M; Nagai, Y; Yoshida, K; Abe, Y; Takamori, H; Takahashi, H Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists. Bioorg Med Chem Lett 26:4205-10 (2016) [PubMed]  Article 
Target
Name:
Bombesin receptor subtype-3
Synonyms:
BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44424.45
Organism:
Homo sapiens (Human)
Description:
Bombesin 3 BRS3 HUMAN::P32247
Residue:
399
Sequence:
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
  
Inhibitor
Name:
BDBM50533327
Synonyms:
CHEMBL4461212
Type:
Small organic molecule
Emp. Form.:
C27H31FN2O4
Mol. Mass.:
466.5444
SMILES:
COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(O)=O)cc1
Structure:
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