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Target
Histamine H1 receptor
Ligand
BDBM50089150
Substrate
n/a
Meas. Tech.
ChEBML_83769
IC50
17±n/a nM
Citation
 Upton, C; Osborne, RH; Jaffar, M Conformationally-restricted ligands for the histamine H1 receptor. Bioorg Med Chem Lett 10:1277-9 (2000) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50089150
Synonyms:
2-Ethyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine | CHEMBL23897
Type:
Small organic molecule
Emp. Form.:
C20H21N
Mol. Mass.:
275.3874
SMILES:
CCN1CCC2=C(C1)C(c1ccccc21)c1ccccc1 |c:5|
Structure:
Search PDB for entries with ligand similarity: