Target
Presenilin-1
Ligand
BDBM50534353
Substrate
n/a
Meas. Tech.
ChEMBL_1928511 (CHEMBL4431687)
EC50
6.0±n/a nM
Citation
 Bursavich, MGHarrison, BABlain, JF Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon? J Med Chem 59:7389-409 (2016) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50534353
Synonyms:
CHEMBL4578751
Type:
Small organic molecule
Emp. Form.:
C24H25FN6O
Mol. Mass.:
432.4933
SMILES:
COc1cc(Nc2nc3[C@@H](CCCCn3n2)c2ccc(F)cc2)ccc1-n1cnc(C)c1 |r|
Structure:
Search PDB for entries with ligand similarity: