Reaction Details Report a problem with these data
Target
Presenilin-1
Ligand
BDBM50534360
Substrate
n/a
Meas. Tech.
ChEMBL_1928520 (CHEMBL4431696)
EC50
6.0±n/a nM
Citation
 Bursavich, MG; Harrison, BA; Blain, JF Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon? J Med Chem 59:7389-409 (2016) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50534360
Synonyms:
CHEMBL4538043
Type:
Small organic molecule
Emp. Form.:
C24H26N6OS
Mol. Mass.:
446.568
SMILES:
COc1cc(ccc1-n1cnc(C)c1)-c1csc(n1)N1CCCn2nc3CCCCc3c12
Structure:
Search PDB for entries with ligand similarity: