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Target
Substance-K receptor
Ligand
BDBM50090487
Substrate
n/a
Meas. Tech.
ChEBML_208834
IC50
45±n/a nM
Citation
 Nishi, T; Ishibashi, K; Takemoto, T; Nakajima, K; Fukazawa, T; Iio, Y; Itoh, K; Mukaiyama, O; Yamaguchi, T Combined tachykinin receptor antagonist: synthesis and stereochemical structure-activity relationships of novel morpholine analogues. Bioorg Med Chem Lett 10:1665-8 (2000) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK2R_CAVPO | Neurokinin 2 receptor | Neurokinin NK2 | Substance-K receptor | TACR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45106.00
Organism:
GUINEA PIG
Description:
Neurokinin NK2 TACR2 GUINEA PIG::Q64077
Residue:
402
Sequence:
MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAIDRYMAIVHPFQPRLSAPSTKAVIGGIWLVALALAFPQCFYSTITEDEGATKCVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRAVPRHQAHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSFSLRVNRCHTKEILFMAGDTVPSEATNGQAGGPQDRESVELSSLPGCRAGPSILAKASS
  
Inhibitor
Name:
BDBM50090487
Synonyms:
CHEMBL298247 | spiro[(2-hydroxy)indane-1,40-piperidine] analogue
Type:
Small organic molecule
Emp. Form.:
C35H40Cl2N2O6
Mol. Mass.:
655.608
SMILES:
COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)[C@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Structure:
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