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Target
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Ligand
BDBM50535442
Substrate
n/a
Meas. Tech.
ChEMBL_1930615 (CHEMBL4433866)
EC50
11000±n/a nM
Citation
 Romanelli, MN; Del Lungo, M; Guandalini, L; Zobeiri, M; Gyökeres, A; Árpádffy-Lovas, T; Koncz, I; Sartiani, L; Bartolucci, G; Dei, S; Manetti, D; Teodori, E; Budde, T; Cerbai, E EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating Hyperpolarization-Activated Current in Tissues. ACS Med Chem Lett 10:584-589 (2019) [PubMed]  Article 
Target
Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Synonyms:
BCNG-3 | Bcng3 | Brain cyclic nucleotide-gated channel 3 | HCN4_MOUSE | Hcn4 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Type:
PROTEIN
Mol. Mass.:
127444.97
Organism:
Mus musculus
Description:
ChEMBL_118899
Residue:
1186
Sequence:
MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGRQDPSRRSIRLRPLPSPSPSVAAGCSESRGAALGATESEGPGRSAGKSSTNGDCRRFRGSLASLGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPPGLATEPERPATAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAAIDHILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFVVDFISSIPVEYIFLIVETRIDSEVYKTARAVRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETRLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRKKNSILLHKVQHDLNSGVFNYQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSPPPGACGSPPAPTPSTSTAAAASTTGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLAAGPSSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESVAAFSLYPRAGGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLTTAAPQREPGARSEPVRSKLPSNL
  
Inhibitor
Name:
BDBM50535442
Synonyms:
CHEMBL4453882
Type:
Small organic molecule
Emp. Form.:
C29H40N2O5
Mol. Mass.:
496.6383
SMILES:
COc1ccc(CCN(C)[C@@H]2CCC[C@@H](C2)N2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC |r|
Structure:
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