Reaction Details Report a problem with these data
Target
Erythropoietin receptor
Ligand
BDBM50091842
Substrate
n/a
Meas. Tech.
ChEBML_67869
IC50
35000±n/a nM
Citation
 Connolly, PJ; Wetter, SK; Murray, WV; Johnson, DL; McMahon, FJ; Farrell, FX; Tullai, J; Jolliffe, LK Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids. Bioorg Med Chem Lett 10:1995-9 (2001) [PubMed]  Article 
Target
Name:
Erythropoietin receptor
Synonyms:
EPO-R | EPOR | EPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
55040.56
Organism:
Homo sapiens (Human)
Description:
ChEMBL_67864
Residue:
508
Sequence:
MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
  
Inhibitor
Name:
BDBM50091842
Synonyms:
(S)-2-{Bis-[(E)-3-(3-phenoxy-phenyl)-allyl]-amino}-6-ureido-hexanoic acid methyl ester | CHEMBL59332
Type:
Small organic molecule
Emp. Form.:
C38H41N3O5
Mol. Mass.:
619.7492
SMILES:
COC(=O)[C@H](CCCCNC(N)=O)N(C\C=C\c1cccc(Oc2ccccc2)c1)C\C=C\c1cccc(Oc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: