Reaction Details Report a problem with these data
Target
DNA polymerase catalytic subunit
Ligand
BDBM50091986
Substrate
n/a
Meas. Tech.
ChEBML_157582
IC50
760±n/a nM
Citation
 Vaillancourt, VA; Cudahy, MM; Staley, SA; Brideau, RJ; Conrad, SJ; Knechtel, ML; Oien, NL; Wieber, JL; Yagi, Y; Wathen, MW Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase. Bioorg Med Chem Lett 10:2079-81 (2000) [PubMed]  Article 
Target
Name:
DNA polymerase catalytic subunit
Synonyms:
DPOL_HHV6U | Human herpesvirus 6 DNA polymerase | U38 | XILF0
Type:
PROTEIN
Mol. Mass.:
115827.55
Organism:
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human Blymphotropic virus)
Description:
ChEMBL_157582
Residue:
1012
Sequence:
MDSVSFFNPYLEANRLKKKSRSSYIRILPRGIMHDGAAGLIKDVCDSEPRMFYRDRQYLLSKEMTWPSLDIARSKDYDHMRMKFHIYDAVETLMFTDSIENLPFQYRHFVIPSGTVIRMFGRTEDGEKICVNVFGQEQYFYCECVDGRSLKATINNLMLTGEVKMSCSFVIEPADKLSLYGYNANTVVNLFKVSFGNFYVSQRIGKILQNEGFVVYEIDVDVLTRFFVDNGFLSFGWYNVKKYIPQDMGKGSNLEVEINCHVSDLVSLEDVNWPLYGCWSFDIECLGQNGNFPDAENLGDIVIQISVISFDTEGDRDERHLFTLGTCEKIDGVHIYEFASEFELLLGFFIFLRIESPEFITGYNINNFDLKYLCIRMDKIYHYDIGCFSKLKNGKIGISVPHEQYRKGFLQAQTKVFTSGVLYLDMYPVYSSKITAQNYKLDTIAKICLQQEKEQLSYKEIPKKFISGPSGRAVVGKYCLQDSVLVVRLFKQINYHFEVAEVARLAHVTARCVVFEGQQKKIFPCILTEAKRRNMILPSMVSSHNRQGIGYKGATVLEPKTGYYAVPTVVFDFQSLYPSIMMAHNLCYSTLVLDERQIAGLSESDILTVKLGDETHRFVKPCIRESVLGSLLKDWLAKRREVKAEMQNCSDPMMKLLLDKKQLALKTTCNSVYGVTGAAHGLLPCVAIAASVTCLGREMLCSTVDYVNSKMQSEQFFCEEFGLTSSDFTGDLEVEVIYGDTDSIFMSVRNMVNQSLRRIAPMIAKHITDRLFKSPIKLEFEKILCPLILICKKRYIGRQDDSLLIFKGVDLVRKTSCDFVKGVVKDIVDLLFFDEEVQTAAVEFSHMTQTQLREQGVPVGIHKILRRLCEAREELFQNRADVRHLMLSSVLSKEMAAYKQPNLAHLSVIRRLAQRKEEIPNVGDRIMYVLIAPSIGNKQTHNYELAEDPNYVIEHKIPIHAEKYFDQIIKAVTNAISPIFPKTDIKKEKLLLYLLPMKVYLDETFSAIAEVM
  
Inhibitor
Name:
BDBM50091986
Synonyms:
3-Hydroxy-7-methoxy-naphthalene-2-carboxylic acid 4-chloro-benzylamide | CHEMBL66078
Type:
Small organic molecule
Emp. Form.:
C19H16ClNO3
Mol. Mass.:
341.788
SMILES:
COc1ccc2cc(O)c(cc2c1)C(=O)NCc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: