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Target
DNA polymerase catalytic subunit
Ligand
BDBM50092001
Substrate
n/a
Meas. Tech.
ChEBML_157582
IC50
2400±n/a nM
Citation
 Vaillancourt, VA; Cudahy, MM; Staley, SA; Brideau, RJ; Conrad, SJ; Knechtel, ML; Oien, NL; Wieber, JL; Yagi, Y; Wathen, MW Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase. Bioorg Med Chem Lett 10:2079-81 (2000) [PubMed]  Article 
Target
Name:
DNA polymerase catalytic subunit
Synonyms:
DPOL_HHV6U | Human herpesvirus 6 DNA polymerase | U38 | XILF0
Type:
PROTEIN
Mol. Mass.:
115827.55
Organism:
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human Blymphotropic virus)
Description:
ChEMBL_157582
Residue:
1012
Sequence:
MDSVSFFNPYLEANRLKKKSRSSYIRILPRGIMHDGAAGLIKDVCDSEPRMFYRDRQYLLSKEMTWPSLDIARSKDYDHMRMKFHIYDAVETLMFTDSIENLPFQYRHFVIPSGTVIRMFGRTEDGEKICVNVFGQEQYFYCECVDGRSLKATINNLMLTGEVKMSCSFVIEPADKLSLYGYNANTVVNLFKVSFGNFYVSQRIGKILQNEGFVVYEIDVDVLTRFFVDNGFLSFGWYNVKKYIPQDMGKGSNLEVEINCHVSDLVSLEDVNWPLYGCWSFDIECLGQNGNFPDAENLGDIVIQISVISFDTEGDRDERHLFTLGTCEKIDGVHIYEFASEFELLLGFFIFLRIESPEFITGYNINNFDLKYLCIRMDKIYHYDIGCFSKLKNGKIGISVPHEQYRKGFLQAQTKVFTSGVLYLDMYPVYSSKITAQNYKLDTIAKICLQQEKEQLSYKEIPKKFISGPSGRAVVGKYCLQDSVLVVRLFKQINYHFEVAEVARLAHVTARCVVFEGQQKKIFPCILTEAKRRNMILPSMVSSHNRQGIGYKGATVLEPKTGYYAVPTVVFDFQSLYPSIMMAHNLCYSTLVLDERQIAGLSESDILTVKLGDETHRFVKPCIRESVLGSLLKDWLAKRREVKAEMQNCSDPMMKLLLDKKQLALKTTCNSVYGVTGAAHGLLPCVAIAASVTCLGREMLCSTVDYVNSKMQSEQFFCEEFGLTSSDFTGDLEVEVIYGDTDSIFMSVRNMVNQSLRRIAPMIAKHITDRLFKSPIKLEFEKILCPLILICKKRYIGRQDDSLLIFKGVDLVRKTSCDFVKGVVKDIVDLLFFDEEVQTAAVEFSHMTQTQLREQGVPVGIHKILRRLCEAREELFQNRADVRHLMLSSVLSKEMAAYKQPNLAHLSVIRRLAQRKEEIPNVGDRIMYVLIAPSIGNKQTHNYELAEDPNYVIEHKIPIHAEKYFDQIIKAVTNAISPIFPKTDIKKEKLLLYLLPMKVYLDETFSAIAEVM
  
Inhibitor
Name:
BDBM50092001
Synonyms:
3-Hydroxy-7-methoxy-naphthalene-2-carboxylic acid [4-(3-nitro-phenyl)-thiazol-2-yl]-amide | CHEMBL65757
Type:
Small organic molecule
Emp. Form.:
C21H15N3O5S
Mol. Mass.:
421.426
SMILES:
COc1ccc2cc(O)c(cc2c1)C(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O
Structure:
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