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Target
Beta-2 adrenergic receptor
Ligand
BDBM50093038
Substrate
n/a
Meas. Tech.
ChEMBL_38314 (CHEMBL647877)
IC50
760±n/a nM
Citation
 Parmee, ER; Brockunier, LL; He, J; Singh, SB; Candelore, MR; Cascieri, MA; Deng, L; Liu, Y; Tota, L; Wyvratt, MJ; Fisher, MH; Weber, AE Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists. Bioorg Med Chem Lett 10:2283-6 (2001) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50093038
Synonyms:
1-(3',4',5'-Trimethoxy-biphenyl-4-ylmethyl)-1,2,3,4-tetrahydro-isoquinoline-6,7-diol | CHEMBL421871
Type:
Small organic molecule
Emp. Form.:
C25H27NO5
Mol. Mass.:
421.4856
SMILES:
COc1cc(cc(OC)c1OC)-c1ccc(CC2NCCc3cc(O)c(O)cc23)cc1
Structure:
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