Reaction Details Report a problem with these data
Target
Papain
Ligand
BDBM50094933
Substrate
n/a
Meas. Tech.
ChEBML_152642
IC50
200±n/a nM
Citation
 Schirmeister, T (S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors. Bioorg Med Chem Lett 10:2647-51 (2000) [PubMed]  Article 
Target
Name:
Papain
Synonyms:
Allergen=Car p 1 | PAPA1_CARPA | PPI | Papaya proteinase I
Type:
Enzyme
Mol. Mass.:
38923.01
Organism:
Carica papaya
Description:
Papain was purchased from Sigma, Germany.
Residue:
345
Sequence:
MAMIPSISKLLFVAICLFVYMGLSFGDFSIVGYSQNDLTSTERLIQLFESWMLKHNKIYKNIDEKIYRFEIFKDNLKYIDETNKKNNSYWLGLNVFADMSNDEFKEKYTGSIAGNYTTTELSYEEVLNDGDVNIPEYVDWRQKGAVTPVKNQGSCGSCWAFSAVVTIEGIIKIRTGNLNEYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNEGALLYSIANQPVSVVLEAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
  
Inhibitor
Name:
BDBM50094933
Synonyms:
(S)-Thiirane-2-carboxylic acid methyl ester | CHEMBL89706
Type:
Small organic molecule
Emp. Form.:
C4H6O2S
Mol. Mass.:
118.154
SMILES:
COC(=O)[C@H]1CS1
Structure:
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