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Target
Adenosine kinase
Ligand
BDBM50095360
Substrate
n/a
Meas. Tech.
ChEMBL_31129 (CHEMBL643557)
IC50
550±n/a nM
Citation
 Cowart, M; Lee, CH; Gfesser, GA; Bayburt, EK; Bhagwat, SS; Stewart, AO; Yu, H; Kohlhaas, KL; McGaraughty, S; Wismer, CT; Mikusa, J; Zhu, C; Alexander, KM; Jarvis, MF; Kowaluk, EA Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors. Bioorg Med Chem Lett 11:83-6 (2001) [PubMed]  Article 
Target
Name:
Adenosine kinase
Synonyms:
ADENOSINE | ADK_RAT | Adenosine 5-phosphotransferase | Adenosine Kinase (AK) | Adenosine kinase | Adk
Type:
Enzyme
Mol. Mass.:
40130.14
Organism:
Rattus norvegicus (rat)
Description:
Rat brain cytosol as enzyme source.
Residue:
361
Sequence:
MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNETEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPVLDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
  
Inhibitor
Name:
BDBM50095360
Synonyms:
7-(6-Morpholin-4-yl-pyridin-3-yl)-5-thiophen-3-yl-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL354881
Type:
Small organic molecule
Emp. Form.:
C20H18N6OS
Mol. Mass.:
390.462
SMILES:
Nc1ncnc2nc(cc(-c3ccsc3)c12)-c1ccc(nc1)N1CCOCC1
Structure:
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