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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50095694
Substrate
n/a
Meas. Tech.
ChEMBL_201561 (CHEMBL804716)
Ki
9800±n/a nM
Citation
 May, EL; Jacobson, AE; Mattson, MV; Traynor, JR; Woods, JH; Harris, LS; Bowman, ER; Aceto, MD Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. J Med Chem 43:5030-6 (2001) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor, sigma 1 | Oprs1 | SGMR1_MOUSE | Sigma 1-type opioid receptor | Sigma1-receptor | Sigma1R | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25246.51
Organism:
Mus musculus (Mouse)
Description:
O55242
Residue:
223
Sequence:
MPWAAGRRWAWITLILTIIAVLIQAAWLWLGTQNFVFSREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCILHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWKEGTTKSEVFYPGETVVHGPGEATALEWGPNTWMVEYGRGVIPSTLFFALADTFFSTQDYLTLFYTLRAYARGLRLELTTYLFGQDS
  
Inhibitor
Name:
BDBM50095694
Synonyms:
3-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-yl)-propionitrile | CHEMBL149491
Type:
Small organic molecule
Emp. Form.:
C17H22N2O
Mol. Mass.:
270.3694
SMILES:
C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2CCC#N |TLB:16:15:1:10.4.3,9:10:1:15.13.14|
Structure:
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