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Target
Cathepsin K
Ligand
BDBM50096366
Substrate
n/a
Meas. Tech.
ChEBML_48320
Ki
53±n/a nM
Citation
 Fenwick, AE; Garnier, B; Gribble, AD; Ife, RJ; Rawlings, AD; Witherington, J Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K. Bioorg Med Chem Lett 11:195-8 (2001) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50096366
Synonyms:
Benzofuran-2-carboxylic acid [(S)-3-methyl-1-(4-oxo-tetrahydro-furan-3-ylcarbamoyl)-butyl]-amide | CHEMBL300347
Type:
Small organic molecule
Emp. Form.:
C19H22N2O5
Mol. Mass.:
358.3884
SMILES:
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)NC1COCC1=O
Structure:
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