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TargetCytosolic phospholipase A2 gamma
LigandBDBM50097334
Substrate/Competitorn/a
Meas. Tech.ChEBML_52417
IC50 4.2±n/a nM
Citation Seno, KOkuno, TNishi, KMurakami, YYamada, KNakamoto, SOno, T Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. Bioorg Med Chem Lett11:587-90 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytosolic phospholipase A2 gamma
Name:Cytosolic phospholipase A2 gamma
Synonyms:Phospholipase A2 group IVC | cPLA2-gamma
Type:PROTEIN
Mol. Mass.:60942.45
Organism:Homo sapiens (Human)
Description:ChEMBL_52417
Residue:541
Sequence:
MGSSEVSIIPGLQKEEKAAVERRRLHVLKALKKLRIEADEAPVVAVLGSGGGLRAHIACL
GVLSEMKEQGLLDAVTYLAGVSGSTWAISSLYTNDGDMEALEADLKHRFTRQEWDLAKSL
QKTIQAARSENYSLTDFWAYMVISKQTRELPESHLSNMKKPVEEGTLPYPIFAAIDNDLQ
PSWQEARAPETWFEFTPHHAGFSALGAFVSITHFGSKFKKGRLVRTHPERDLTFLRGLWG
SALGNTEVIREYIFDQLRNLTLKGLWRRAVANAKSIGHLIFARLLRLQESSQGEHPPPED
EGGEPEHTWLTEMLENWTRTSLEKQEQPHEDPERKGSLSNLMDFVKKTGICASKWEWGTT
HNFLYKHGGIRDKIMSSRKHLHLVDAGLAINTPFPLVLPPTREVHLILSFDFSAGDPFET
IRATTDYCRRHKIPFPQVEEAELDLWSKAPASCYILKGETGPVVMHFPLFNIDACGGDIE
AWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSARSCCL
A
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  Blast E-value cutoff:
BDBM50097334
NameBDBM50097334
Synonyms:CHEMBL385730 | N-[(2S,4R)-1-[2-(2,4-Difluoro-benzoyl)-benzoyl]-4-(triphenyl-lambda*4*-sulfanyl)-pyrrolidin-2-ylmethyl]-4-[2,4-dioxo-thiazolidin-(5Z)-ylidenemethyl]-benzamide
TypeSmall organic molecule
Emp. Form.C48H37F2N3O5S2
Mol. Mass.837.951
SMILESOC1=NC(=O)C(S1)=Cc1ccc(cc1)C(=O)NC[C@@H]1C[C@H](CN1C(=O)c1ccccc1C(=O)c1ccc(F)cc1F)S(c1ccccc1)(c1ccccc1)c1ccccc1 |w:7.8,t:1|
Structure
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n/a