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TargetSerotonin (5-HT) receptor
LigandBDBM50097342
Substrate/Competitorn/a
Meas. Tech.ChEBML_830
IC50 0.470000±n/a nM
Citation Kamei, KMaeda, NOgino, RKoyama, MNakajima, MTatsuoka, TOhno, TInoue, T New 5-HT1A receptor agonists possessing 1,4-benzoxazepine scaffold exhibit highly potent anti-ischemic effects. Bioorg Med Chem Lett11:595-8 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serotonin (5-HT) receptor
Name:Serotonin 1 (5-HT1) receptor
Synonyms:5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A | 5-hydroxytryptamine receptor 1A (5HT1A) | G-21 | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46445.29
Organism:Rattus norvegicus (rat)
Description:Binding assays were performed using rat hippocampal membranes.
Residue:422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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  Blast E-value cutoff:
BDBM50097342
NameBDBM50097342
Synonyms:3-Chloro-4-[4-(3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-yl)-butyl]-4H-benzo[f][1,4]oxazepin-5-one | CHEMBL345237
TypeSmall organic molecule
Emp. Form.C23H24ClN3O2
Mol. Mass.409.909
SMILESClC1=COc2ccccc2C(=O)N1CCCCN1CCC(=CC1)c1ccccn1 |c:22,t:1|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a