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Target
Sodium/hydrogen exchanger 2
Ligand
BDBM50097897
Substrate
n/a
Meas. Tech.
ChEBML_141049
IC50
3900±n/a nM
Citation
 Guzman-Perez, A; Wester, RT; Allen, MC; Brown, JA; Buchholz, AR; Cook, ER; Day, WW; Hamanaka, ES; Kennedy, SP; Knight, DR; Kowalczyk, PJ; Marala, RB; Mularski, CJ; Novomisle, WA; Ruggeri, RB; Tracey, WR; Hill, RJ Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg Med Chem Lett 11:803-7 (2001) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 2
Synonyms:
NHE-2 | NHE2 | Na(+)/H(+) exchanger 2 | SL9A2_HUMAN | SLC9A2 | Solute carrier family 9 member 2
Type:
PROTEIN
Mol. Mass.:
91542.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_397781
Residue:
812
Sequence:
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
  
Inhibitor
Name:
BDBM50097897
Synonyms:
CHEMBL352933 | N-(5-Methyl-1-phenyl-1H-pyrazole-4-carbonyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C12H13N5O
Mol. Mass.:
243.2645
SMILES:
Cc1c(cnn1-c1ccccc1)C(=O)NC(N)=N
Structure:
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