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Target
Intercellular adhesion molecule 1
Ligand
BDBM50098495
Substrate
n/a
Meas. Tech.
ChEMBL_89064 (CHEMBL697203)
IC50
>100000±n/a nM
Citation
 Stewart, AO; Bhatia, PA; McCarty, CM; Patel, MV; Staeger, MA; Arendsen, DL; Gunawardana, IW; Melcher, LM; Zhu, GD; Boyd, SA; Fry, DG; Cool, BL; Kifle, L; Lartey, K; Marsh, KC; Kempf-Grote, AJ; Kilgannon, P; Wisdom, W; Meyer, J; Gallatin, WM; Okasinski, GF Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J Med Chem 44:988-1002 (2001) [PubMed]  Article 
Target
Name:
Intercellular adhesion molecule 1
Synonyms:
CD_antigen=CD54 | ICAM-1 | ICAM1 | ICAM1_HUMAN | Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 | Intercellular adhesion molecule 1 | Intercellular adhesion molecule-1 | Major group rhinovirus receptor
Type:
PROTEIN
Mol. Mass.:
57831.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_826675
Residue:
532
Sequence:
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
  
Inhibitor
Name:
BDBM50098495
Synonyms:
4-Chloro-6-ethyl-thieno[2,3-d]pyrimidine | CHEMBL269056
Type:
Small organic molecule
Emp. Form.:
C8H7ClN2S
Mol. Mass.:
198.673
SMILES:
CCc1cc2c(Cl)ncnc2s1
Structure:
Search PDB for entries with ligand similarity: