Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50098576
Substrate
n/a
Meas. Tech.
ChEMBL_216562 (CHEMBL822277)
Ki
100±n/a nM
Citation
Marquis, RW; Ru, Y; LoCastro, SM; Zeng, J; Yamashita, DS; Oh, HJ; Erhard, KF; Davis, LD; Tomaszek, TA; Tew, D; Salyers, K; Proksch, J; Ward, K; Smith, B; Levy, M; Cummings, MD; Haltiwanger, RC; Trescher, G; Wang, B; Hemling, ME; Quinn, CJ; Cheng, HY; Lin, F; Smith, WW; Janson, CA; Zhao, B; McQueney, MS; D'Alessio, K; Lee, CP; Marzulli, A; Dodds, RA; Blake, S; Hwang, SM; James, IE; Gress, CJ; Bradley, BR; Lark, MW; Gowen, M; Veber, DF Azepanone-based inhibitors of human and rat cathepsin K. J Med Chem 44:1380-95 (2001) [PubMed] Article
More Info.:
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Inhibitor
Name:
BDBM50098576
Synonyms:
5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE | 5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid (3-methyl-1-{3-oxo-1-[2-(3-pyridin-2-yl-phenyl)-acetyl]-azepan-4-ylcarbamoyl}-butyl)-amide | CHEMBL284939
Type:
Small organic molecule
Emp. Form.:
C40H47N5O7
Mol. Mass.:
709.8305
SMILES:
CC(C)C[C@H](NC(=O)c1cc2cc(OCCN3CCOCC3)ccc2o1)C(=O)N[C@H]1CCCN(CC1=O)C(=O)Cc1cccc(c1)-c1ccccn1