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Target
Glutamate carboxypeptidase 2
Ligand
BDBM50099220
Substrate
n/a
Meas. Tech.
ChEMBL_158618 (CHEMBL765764)
IC50
11500±n/a nM
Citation
 Adlington, RM; Baldwin, JE; Becker, GW; Chen, B; Cheng, L; Cooper, SL; Hermann, RB; Howe, TJ; McCoull, W; McNulty, AM; Neubauer, BL; Pritchard, GJ Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen. J Med Chem 44:1491-508 (2001) [PubMed]  Article 
Target
Name:
Glutamate carboxypeptidase 2
Synonyms:
FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP
Type:
PROTEIN
Mol. Mass.:
84333.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497035
Residue:
750
Sequence:
MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGEVKRQIYVAAFTVQAAAETLSEVA
  
Inhibitor
Name:
BDBM50099220
Synonyms:
Benzoic acid 3-benzyl-1-(4-nitro-benzenesulfonyl)-4-oxo-azetidin-2-ylmethyl ester | CHEMBL36676
Type:
Small organic molecule
Emp. Form.:
C24H20N2O7S
Mol. Mass.:
480.49
SMILES:
[O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1[C@H](COC(=O)c2ccccc2)[C@H](Cc2ccccc2)C1=O
Structure:
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