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Target
Estrogen receptor beta
Ligand
BDBM50099586
Substrate
n/a
Meas. Tech.
ChEMBL_67341 (CHEMBL677746)
IC50
242±n/a nM
Citation
 Miller, CP; Collini, MD; Tran, BD; Harris, HA; Kharode, YP; Marzolf, JT; Moran, RA; Henderson, RA; Bender, RH; Unwalla, RJ; Greenberger, LM; Yardley, JP; Abou-Gharbia, MA; Lyttle, CR; Komm, BS Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens. J Med Chem 44:1654-7 (2001) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50099586
Synonyms:
2-(4-Hydroxy-phenyl)-3-methyl-1-(6-pyrrolidin-1-yl-hexyl)-1H-indol-5-ol | CHEMBL46903 | ZK-119010
Type:
Small organic molecule
Emp. Form.:
C25H32N2O2
Mol. Mass.:
392.5338
SMILES:
Cc1c(-c2ccc(O)cc2)n(CCCCCCN2CCCC2)c2ccc(O)cc12
Structure:
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