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Target
Urokinase-type plasminogen activator
Ligand
BDBM50099912
Substrate
n/a
Meas. Tech.
ChEBML_213135
Ki
6000±n/a nM
Citation
 Subasinghe, NL; Illig, C; Hoffman, J; Rudolph, MJ; Wilson, KJ; Soll, R; Randle, T; Green, D; Lewandowski, F; Zhang, M; Bone, R; Spurlino, J; DesJarlais, R; Deckman, I; Molloy, CJ; Manthey, C; Zhou, Z; Sharp, C; Maguire, D; Crysler, C; Grasberger, B Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors. Bioorg Med Chem Lett 11:1379-82 (2001) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50099912
Synonyms:
5-Methylsulfanyl-thiophene-2-carboxamidine | CHEMBL28890
Type:
Small organic molecule
Emp. Form.:
C6H8N2S2
Mol. Mass.:
172.271
SMILES:
CSc1ccc(s1)C(N)=N
Structure:
Search PDB for entries with ligand similarity: