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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50101189
Substrate
n/a
Meas. Tech.
ChEMBL_71606 (CHEMBL689138)
IC50
0.100000±n/a nM
Citation
 Ashton, WT; Sisco, RM; Yang, YT; Lo, JL; Yudkovitz, JB; Cheng, K; Goulet, MT Substituted indole-5-carboxamides and -acetamides as potent nonpeptide GnRH receptor antagonists. Bioorg Med Chem Lett 11:1723-6 (2001) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50101189
Synonyms:
CHEMBL49891 | N-{4-[4-(2-{2-(3,5-Dimethyl-phenyl)-5-[2-(2,5-dimethyl-pyrrolidin-1-yl)-2-oxo-ethyl]-1H-indol-3-yl}-ethylamino)-butyl]-phenyl}-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C37H48N4O3S
Mol. Mass.:
628.867
SMILES:
CC1CCC(C)N1C(=O)Cc1ccc2[nH]c(c(CCNCCCCc3ccc(NS(C)(=O)=O)cc3)c2c1)-c1cc(C)cc(C)c1
Structure:
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