Reaction Details Report a problem with these data
Target
Probable G-protein coupled receptor 142
Ligand
BDBM332764
Substrate
n/a
Meas. Tech.
ChEMBL_1993751 (CHEMBL4627646)
EC50
27±n/a nM
Citation
 Liu, LZ; Ma, T; Zhou, J; Long Hu, Z; Jun Zhang, X; Zhen Zhang, H; Zeng, M; Liu, J; Li, L; Jiang, Y; Zou, Z; Wang, F; Zhang, L; Xu, J; Wang, J; Xiao, F; Fang, X; Zou, H; Efanov, AM; Thomas, MK; Lin, HV; Chen, J Discovery of LY3325656: A GPR142 agonist suitable for clinical testing in human. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 142
Synonyms:
G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2
Type:
PROTEIN
Mol. Mass.:
51127.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_985961
Residue:
462
Sequence:
MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
  
Inhibitor
Name:
BDBM332764
Synonyms:
Cis-(chiral)-3-Chloro-N-[2- [5-(1,4-dimethyl-1H- imidazol-5-yl)-4H-1,2,4- triazol-3-yl]tetrahydro-2H- pyran-4-yl]-N-methyl- benzamide, Isomer 1 | US10196385, Example 3
Type:
Small organic molecule
Emp. Form.:
C20H23ClN6O2
Mol. Mass.:
414.889
SMILES:
CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(Cl)c1 |r|
Structure:
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