Reaction Details Report a problem with these data
Target
P2X purinoceptor 6
Ligand
BDBM85043
Substrate
n/a
Meas. Tech.
ChEMBL_147558 (CHEMBL751128)
IC50
2000±n/a nM
Citation
 Kim, YC; Brown, SG; Harden, TK; Boyer, JL; Dubyak, G; King, BF; Burnstock, G; Jacobson, KA Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem 44:340-9 (2001) [PubMed]  Article 
Target
Name:
P2X purinoceptor 6
Synonyms:
ATP receptor | P2RX6_RAT | P2X6 | P2XM | P2rx6 | P2rxl1 | Purinergic receptor | Purinergic receptor P2X-like 1
Type:
PROTEIN
Mol. Mass.:
42451.11
Organism:
Rattus norvegicus
Description:
ChEMBL_147419
Residue:
379
Sequence:
MASAVAAALVSWGFLDYKTEKYVMTRNCWVGISQRLLQLGVVVYVIGWALLAKKGYQEWDMDPQISVITKLKGVSVTQVKELEKRLWDVADFVRPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWADEDCPEGEMGTYSHGIKTGQCVAFNGTHRTCEIWSWCPVESSAVPRKPLLAQAKNFTLFIKNTVTFNKFNFSRTNALDTWDNTYFKYCLYDSLSSPYCPVFRIGDLVAMTGGDFEDLALLGGAVGINIHWDCNLDTKGSDCSPQYSFQLQERGYNFRTANYWWAASGVESRSLLKLYGIRFDILVTGQAGKFALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKYEEARAPKATTNSA
  
Inhibitor
Name:
BDBM85043
Synonyms:
CAS_149017-66-3 | CHEMBL69234 | NSC_6093163 | PPADS
Type:
Small organic molecule
Emp. Form.:
C14H14N3O12PS2
Mol. Mass.:
511.378
SMILES:
Cc1nc(N=Nc2ccc(cc2S(O)(=O)=O)S(O)(=O)=O)c(COP(O)(O)=O)c(C=O)c1O |w:4.3|
Structure:
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