Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 1
Ligand
BDBM50103033
Substrate
n/a
Meas. Tech.
ChEMBL_90174 (CHEMBL697152)
IC50
620±n/a nM
Citation
Zhang, HC; McComsey, DF; White, KB; Addo, MF; Andrade-Gordon, P; Derian, CK; Oksenberg, D; Maryanoff, BE Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide. Bioorg Med Chem Lett 11:2105-9 (2001) [PubMed] Article
More Info.:
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
Inhibitor
Name:
BDBM50103033
Synonyms:
(S)-2-((S)-3-(4-Cyano-phenyl)-2-{3-[1-(2-methyl-benzyl)-3-pyrrolidin-1-ylmethyl-1H-indol-6-yl]-ureido}-propionylamino)-5-guanidino-pentanoic acid benzylamide | CHEMBL66585
Type:
Small organic molecule
Emp. Form.:
C45H52N10O3
Mol. Mass.:
780.9596
SMILES:
Cc1ccccc1Cn1cc(CN2CCCC2)c2ccc(NC(=O)N[C@@H](Cc3ccc(cc3)C#N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCc3ccccc3)cc12