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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50103051
Substrate
n/a
Meas. Tech.
ChEBML_202785
IC50
1200±n/a nM
Citation
 Lesuisse, D; Deprez, P; Albert, E; Duc, TT; Sortais, B; Gofflo, D; Jean-Baptiste, V; Marquette, J; Schoot, B; Sarubbi, E; Lange, G; Broto, P; Mandine, E Discovery of thioazepinone ligands for Src SH2: from non-specific to specific binding. Bioorg Med Chem Lett 11:2127-31 (2001) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50103051
Synonyms:
CHEMBL66294 | Phosphoric acid mono-(4-{(S)-2-acetylamino-2-[(R)-4-(4-chloro-benzo[1,3]dioxol-5-ylmethyl)-5-oxo-[1,4]thiazepan-6-ylcarbamoyl]-ethyl}-phenyl) ester
Type:
Small organic molecule
Emp. Form.:
C24H27ClN3O9PS
Mol. Mass.:
599.978
SMILES:
CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@H]1CSCCN(Cc2ccc3OCOc3c2Cl)C1=O
Structure:
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