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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50103234
Substrate
n/a
Meas. Tech.
ChEMBL_162609 (CHEMBL771321)
Ki
900000±n/a nM
Citation
 Gao, Y; Voigt, J; Zhao, H; Pais, GC; Zhang, X; Wu, L; Zhang, ZY; Burke, TR Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif. J Med Chem 44:2869-78 (2001) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50103234
Synonyms:
2-Carboxymethoxy-naphthalene-1,6-dicarboxylic acid | CHEMBL96035
Type:
Small organic molecule
Emp. Form.:
C14H10O7
Mol. Mass.:
290.225
SMILES:
OC(=O)COc1ccc2cc(ccc2c1C(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: