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Target
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Ligand
BDBM50104047
Substrate
n/a
Meas. Tech.
ChEMBL_70756 (CHEMBL682843)
IC50
35±n/a nM
Citation
 Böhm, M; Mitsch, A; Wissner, P; Sattler, I; Schlitzer, M Exploration of novel aryl binding sites of farnesyltransferase using molecular modeling and benzophenone-based farnesyltransferase inhibitors. J Med Chem 44:3117-24 (2001) [PubMed]  Article 
Target
Name:
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Farnesyltransferase | Farnesyltransferase (FTase) | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 70753
Components:
This complex has 2 components.
Component 1
Name:
Protein farnesyltransferase subunit beta
Synonyms:
CAAX farnesyltransferase subunit beta | DPR1 | FNTB_YEAST | FTase-beta | Farnesyltransferase | RAM1 | Ras proteins prenyltransferase subunit beta | SCG2 | STE16
Type:
Protein
Mol. Mass.:
48188.41
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P22007
Residue:
431
Sequence:
MRQRVGRSIARAKFINTALLGRKRPVMERVVDIAHVDSSKAIQPLMKELETDTTEARYKVLQSVLEIYDDEKNIEPALTKEFHKMYLDVAFEISLPPQMTALDASQPWMLYWIANSLKVMDRDWLSDDTKRKIVDKLFTISPSGGPFGGGPGQLSHLASTYAAINALSLCDNIDGCWDRIDRKGIYQWLISLKEPNGGFKTCLEVGEVDTRGIYCALSIATLLNILTEELTEGVLNYLKNCQNYEGGFGSCPHVDEAHGGYTFCATASLAILRSMDQINVEKLLEWSSARQLQEERGFCGRSNKLVDGCYSFWVGGSAAILEAFGYGQCFNKHALRDYILYCCQEKEQPGLRDKPGAHSDFYHTNYCLLGLAVAESSYSCTPNDSPHNIKCTPDRLIGSSKLTDVNPVYGLPIENVRKIIHYFKSNLSSPS
  
Component 2
Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
CAAX farnesyltransferase subunit alpha | FNTA_YEAST | FTase-alpha | Farnesyltransferase | GGTase-I-alpha | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | RAM2 | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha
Type:
PROTEIN
Mol. Mass.:
37495.69
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_588425
Residue:
316
Sequence:
MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN
  
Inhibitor
Name:
BDBM50104047
Synonyms:
(E)-N-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide | CHEMBL67122 | N-(3-benzoyl-4-(2-p-tolylacetamido)phenyl)-3-(5-(4-nitrophenyl)furan-2-yl)acrylamide | N-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[(E)-5-(4-nitro-phenyl)-furan-2-yl]-acrylamide | N-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylamide
Type:
Small organic molecule
Emp. Form.:
C35H27N3O6
Mol. Mass.:
585.6054
SMILES:
Cc1ccc(CC(=O)Nc2ccc(NC(=O)\C=C\c3ccc(o3)-c3ccc(cc3)[N+]([O-])=O)cc2C(=O)c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: