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Target
Interstitial collagenase
Ligand
BDBM50105425
Substrate
n/a
Meas. Tech.
ChEBML_105987
IC50
475000±n/a nM
Citation
 Becker, DP; Barta, TE; Bedell, L; DeCrescenzo, G; Freskos, J; Getman, DP; Hockerman, SL; Li, M; Mehta, P; Mischke, B; Munie, GE; Swearingen, C; Villamil, CI alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1. Bioorg Med Chem Lett 11:2719-22 (2001) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50105425
Synonyms:
(S)-2-(Benzyl-methyl-amino)-N-hydroxy-3-(4-phenoxy-benzenesulfonyl)-propionamide | CHEMBL93725
Type:
Small organic molecule
Emp. Form.:
C23H24N2O5S
Mol. Mass.:
440.512
SMILES:
CN(Cc1ccccc1)[C@H](CS(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO
Structure:
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