Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50105693
Substrate
n/a
Meas. Tech.
ChEMBL_87851 (CHEMBL701991)
IC50
800±n/a nM
Citation
 Lavoie, R; Bouchain, G; Frechette, S; Woo, SH; Abou-Khalil, E; Leit, S; Fournel, M; Yan, PT; Trachy-Bourget, MC; Beaulieu, C; Li, Z; Besterman, J; Delorme, D Design and synthesis of a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett 11:2847-50 (2001) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50105693
Synonyms:
(E)-N-Hydroxy-3-[4-(4-sulfamoyl-benzenesulfonylamino)-phenyl]-acrylamide | CHEMBL95749 | US8796330, 102
Type:
Small organic molecule
Emp. Form.:
C15H15N3O6S2
Mol. Mass.:
397.426
SMILES:
NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1ccc(\C=C\C(=O)NO)cc1
Structure:
Search PDB for entries with ligand similarity: