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Target
Cytochrome P450 2C18
Ligand
BDBM50105810
Substrate
n/a
Meas. Tech.
ChEMBL_51520 (CHEMBL660380)
IC50
3000±n/a nM
Citation
 Ha-Duong, NT; Dijols, S; Marques-Soares, C; Minoletti, C; Dansette, PM; Mansuy, D Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily. J Med Chem 44:3622-31 (2001) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C18
Synonyms:
CP2CI_HUMAN | CYP2C18 | CYPIIC18 | P450-6B/29C
Type:
PROTEIN
Mol. Mass.:
55714.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_51520
Residue:
490
Sequence:
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
  
Inhibitor
Name:
BDBM50105810
Synonyms:
3'-Amino-biphenyl-4-sulfonic acid (3-hydroxy-propyl)-(2-phenyl-2H-pyrazol-3-yl)-amide | CHEMBL121503
Type:
Small organic molecule
Emp. Form.:
C24H24N4O3S
Mol. Mass.:
448.537
SMILES:
Nc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N(CCCO)c1ccnn1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: