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TargetVoltage-gated potassium channel subunit Kv7.1
LigandBDBM50106178
Substrate/Competitorn/a
Meas. Tech.ChEMBL_158397
IC50 23±n/a nM
Citation Lloyd, JSchmidt, JBRovnyak, GAhmad, SAtwal, KSBisaha, SNDoweyko, LMStein, PDTraeger, SCMathur, AConder, MLDiMarco, JHarper, TWJenkins-West, TLevesque, PCNormandin, DERussell, ADSerafino, RPSmith, MALodge, NJ Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers. J Med Chem44:3764-7 (2001) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel subunit Kv7.1
Name:Voltage-gated potassium channel subunit Kv7.1
Synonyms:IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 | KQT-like 1 | Potassium voltage-gated channel subfamily KQT member 1
Type:PROTEIN
Mol. Mass.:74450.11
Organism:Cavia porcellus
Description:ChEMBL_88894
Residue:671
Sequence:
MAAASSPPRTERKRGGWGRLLGSRRGSASLAKKCPFSLELAEGGPAGGTLYAPVAPPGAL
SPGSPAPPASPAAPPAGLELGPRPPVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTG
WKCFVYHFAVFLIVLACLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAG
CRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRML
HVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSY
ADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQ
RQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPARSHTLLSPSPKPKKSAMVR
KKKFKPDKDNGVSPGEKMLTVPHITCDPPEERRPDHFSVDGYDSSVRKSPTLLEVSPTHF
MRTNSFAEDLDLEGETLLTPITHVSQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVR
DVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKV
TQLDQRLVVITDMLHQLLSLHQGGPHSGGGPQMVQPCSEDGSIHPELFLPSNSLPTYEQL
TVPQRGPDEAS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50106178
NameBDBM50106178
Synonyms:4-(3-Butyl-[1,2,4]oxadiazol-5-yl)-N-(3,3-dimethyl-butyl)-benzamide | CHEMBL124545
TypeSmall organic molecule
Emp. Form.C19H27N3O2
Mol. Mass.329.4366
SMILESCCCCc1noc(n1)-c1ccc(cc1)C(=O)NCCC(C)(C)C
Structure
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n/a