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Target
Insulin-like growth factor-binding protein 3
Ligand
BDBM50106436
Substrate
n/a
Meas. Tech.
ChEMBL_90405 (CHEMBL698360)
Ki
58±n/a nM
Citation
 Chen, C; Zhu, YF; Liu, XJ; Lu, ZX; Xie, Q; Ling, N Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 44:4001-10 (2001) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 3
Synonyms:
IBP3 | IBP3_HUMAN | IGFBP3 | Insulin-like growth factor binding protein 3
Type:
PROTEIN
Mol. Mass.:
31690.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90404
Residue:
291
Sequence:
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
  
Inhibitor
Name:
BDBM50106436
Synonyms:
(6,7-Dihydroxy-isoquinolin-1-yl)-(3,4-dihydroxy-phenyl)-methanone | CHEMBL128883
Type:
Small organic molecule
Emp. Form.:
C16H11NO5
Mol. Mass.:
297.2622
SMILES:
Oc1ccc(cc1O)C(=O)c1nccc2cc(O)c(O)cc12
Structure:
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