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Target
Beta-3 adrenergic receptor
Ligand
BDBM50106838
Substrate
n/a
Meas. Tech.
ChEBML_39053
Ki
440±n/a nM
Citation
 Gavai, AV; Sher, PM; Mikkilineni, AB; Poss, KM; McCann, PJ; Girotra, RN; Fisher, LG; Wu, G; Bednarz, MS; Mathur, A; Wang, TC; Sun, CQ; Slusarchyk, DA; Skwish, S; Allen, GT; Hillyer, DE; Frohlich, BH; Abboa-Offei, BE; Cap, M; Waldron, TL; George, RJ; Tesfamariam, B; Harper, TW; Ciosek, CP; Young, DA; Dickinson, KE; Seymour, AA; Arbeeny, CM; Washburn, WN BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor. Bioorg Med Chem Lett 11:3041-4 (2001) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50106838
Synonyms:
CHEMBL103118 | N-(2-Hydroxy-5-{1-hydroxy-2-[1-(4-methanesulfonyl-phenyl)-2-phenyl-ethylamino]-ethyl}-phenyl)-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C24H28N2O6S2
Mol. Mass.:
504.619
SMILES:
CS(=O)(=O)Nc1cc(ccc1O)C(O)CNC(Cc1ccccc1)c1ccc(cc1)S(C)(=O)=O
Structure:
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