Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50107253
Substrate
n/a
Meas. Tech.
ChEMBL_1125 (CHEMBL616070)
Ki
676±n/a nM
Citation
 Perrone, RBerardi, FColabufo, NALeopoldo, MLacivita, ETortorella, VLeonardi, APoggesi, ETesta, R trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines. J Med Chem 44:4431-42 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50107253
Synonyms:
1-((6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)-4-(pyridin-2-yl)piperazine | 1-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-4-pyridin-2-yl-piperazine | CHEMBL138900
Type:
Small organic molecule
Emp. Form.:
C21H27N3O
Mol. Mass.:
337.4586
SMILES:
COc1ccc2CC(CN3CCN(CC3)c3ccccn3)CCc2c1
Structure:
Search PDB for entries with ligand similarity: