Reaction Details Report a problem with these data
Target
Protein-tyrosine sulfotransferase 2
Ligand
BDBM50109104
Substrate
n/a
Meas. Tech.
ChEBML_211032
IC50
40000±n/a nM
Citation
 Kehoe, JW; Maly, DJ; Verdugo, DE; Armstrong, JI; Cook, BN; Ouyang, YB; Moore, KL; Ellman, JA; Bertozzi, CR Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly. Bioorg Med Chem Lett 12:329-32 (2002) [PubMed]  Article 
Target
Name:
Protein-tyrosine sulfotransferase 2
Synonyms:
TPST2 | TPST2_HUMAN
Type:
PROTEIN
Mol. Mass.:
41925.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_211032
Residue:
377
Sequence:
MRLSVRRVLLAAGCALVLVLAVQLGQQVLECRAVLAGLRSPRGAMRPEQEELVMVGTNHVEYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGREKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRLFPNSKFLLMVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGKEKCLPVYYEQLVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSKWTGHIPGDVVRDMAQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGDYKTPANLKGYFQVNQNSTSSHLGSS
  
Inhibitor
Name:
BDBM50109104
Synonyms:
6,8-Dichloro-4-oxo-4H-chromene-3-carbaldehyde O-{5-[1-(5-bromo-2-hydroxy-3-nitro-phenyl)-meth-(E)-ylideneaminooxy]-pentyl}-oxime | CHEMBL113219
Type:
Small organic molecule
Emp. Form.:
C22H18BrCl2N3O7
Mol. Mass.:
587.204
SMILES:
Oc1c([CH+][N-]OCCCCCO[N-][CH+]c2coc3c(Cl)cc(Cl)cc3c2=O)cc(Br)cc1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: