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Target
Procathepsin L
Ligand
BDBM50109170
Substrate
n/a
Meas. Tech.
ChEBML_48493
IC50
23±n/a nM
Citation
 Yamamoto, M; Ikeda, S; Kondo, H; Inoue, S Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin. Bioorg Med Chem Lett 12:375-8 (2002) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50109170
Synonyms:
CHEMBL125553 | N*4*-Hydroxy-2-isobutyl-N*1*-[3-methyl-1-(1-methyl-2-oxo-ethylcarbamoyl)-butyl]-succinamide
Type:
Small organic molecule
Emp. Form.:
C17H31N3O5
Mol. Mass.:
357.4451
SMILES:
CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C=O
Structure:
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