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Target
RAS guanyl-releasing protein 1
Ligand
BDBM50057514
Substrate
n/a
Meas. Tech.
ChEMBL_163499 (CHEMBL772411)
Ki
0.85±n/a nM
Citation
 Rong, SB; Enyedy, IJ; Qiao, L; Zhao, L; Ma, D; Pearce, LL; Lorenzo, PS; Stone, JC; Blumberg, PM; Wang, S; Kozikowski, AP Structural basis of RasGRP binding to high-affinity PKC ligands. J Med Chem 45:853-60 (2002) [PubMed]  Article 
Target
Name:
RAS guanyl-releasing protein 1
Synonyms:
GRP1_RAT | RAS guanyl releasing protein 1 | Rasgrp | Rasgrp1
Type:
PROTEIN
Mol. Mass.:
90263.87
Organism:
Rattus norvegicus
Description:
ChEMBL_163499
Residue:
795
Sequence:
MGTLGKAREAPRKPCHGSRAGPKGRLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALEKNSPGICLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEESHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQDVAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRSKSPAVSTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEVVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKTTQTESFPWVGGEMPPGHFVLTSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEVNTLRADNDALKIQLKYAQKQIESLQLGKSNHVLAQMDHGDGT
  
Inhibitor
Name:
BDBM50057514
Synonyms:
(10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one | 13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one (n-octyl-ILV) | CHEMBL285801
Type:
Small organic molecule
Emp. Form.:
C25H39N3O2
Mol. Mass.:
413.5961
SMILES:
CCCCCCCCc1ccc2N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)Cc3c[nH]c1c23
Structure:
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