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Target
Histamine N-methyltransferase
Ligand
BDBM50110296
Substrate
n/a
Meas. Tech.
ChEMBL_87238 (CHEMBL696458)
IC50
48±n/a nM
Citation
 Apelt, J; Ligneau, X; Pertz, HH; Arrang, JM; Ganellin, CR; Schwartz, JC; Schunack, W; Stark, H Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. J Med Chem 45:1128-41 (2002) [PubMed]  Article 
Target
Name:
Histamine N-methyltransferase
Synonyms:
HNMT_RAT | Hnmt
Type:
PROTEIN
Mol. Mass.:
33931.03
Organism:
Rattus norvegicus
Description:
ChEMBL_87236
Residue:
295
Sequence:
MASFMRSLFSDHSRYVESFRRFLNNSTEHQCMQEFMDKKLPGIIARIGETKAEIKILSIGGGAGEIDLQILSKVQAQYPGICINNEVVEPNAEQIVKYKELVAKTSNMENIKFAWHKETSSEYQKRVVEEDEEPPKWDFIHMIQMLYYVKDIPATLKFFHGLLAANAKILIILVSGTSGWEKLWKKYGFRLPRDDLCQYVTSSDLAQILDDLGIKYECYDLLSTMDITDCFIDGNENGDLLWDFLTETCNFIKTAPLDLKEEIMKDLQEPEFSVKKEGKVLFNNNLSFIVVEANV
  
Inhibitor
Name:
BDBM50110296
Synonyms:
CHEMBL14868 | {4-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-butyl}-(1,2,3,4-tetrahydro-acridin-9-yl)-amine; Oxalic acid
Type:
Small organic molecule
Emp. Form.:
C31H41N3O
Mol. Mass.:
471.6767
SMILES:
C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1c2CCCCc2nc2ccccc12
Structure:
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