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TargetCoagulation factor X
LigandBDBM50112496
Substrate/Competitorn/a
Meas. Tech.ChEBML_49302
Ki 0.340000±n/a nM
Citation Wu, SGuilford, WJChou, YLGriedel, BDLiang, ASakata, SShaw, KJTrinh, LXu, WZhao, ZMorrissey, MM Design and synthesis of aminophenol-based factor Xa inhibitors. Bioorg Med Chem Lett12:1307-10 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50112496
NameBDBM50112496
Synonyms:CHEMBL26709 | N-[3-(5-Carbamimidoyl-2-hydroxy-phenyl)-allyl]-N-[4-(1-carboxymethyl-piperidin-4-yloxy)-3-trifluoromethyl-phenyl]-succinamic acid
TypeSmall organic molecule
Emp. Form.C28H31F3N4O7
Mol. Mass.592.5635
SMILESNC(=N)c1ccc(O)c(\C=C\CN(C(=O)CCC(O)=O)c2ccc(OC3CCN(CC(O)=O)CC3)c(c2)C(F)(F)F)c1
Structure
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n/a