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Reaction Details
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TargetCoagulation factor X
LigandBDBM50112494
Substrate/Competitorn/a
Meas. Tech.ChEBML_49327
Ki 0.300000±n/a nM
Citation Shaw, KJGuilford, WJGriedel, BDSakata, STrinh, LWu, SXu, WZhao, ZMorrissey, MM Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity. Bioorg Med Chem Lett12:1311-4 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50112494
NameBDBM50112494
Synonyms:7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-methyl-4-nitro-benzoimidazol-1-ylmethyl}-naphthalene-2-carboxamidine | CHEMBL25351
TypeSmall organic molecule
Emp. Form.C27H29N7O3
Mol. Mass.499.5643
SMILESCC([NH-])=[N+]1CCC(CC1)Oc1ccc2n(Cc3ccc4ccc(cc4c3)C(N)=N)c(C)nc2c1[N+]([O-])=O |(-7.32,-3.83,;-5.99,-4.62,;-5.99,-6.16,;-4.66,-3.85,;-3.33,-4.63,;-1.98,-3.86,;-1.98,-2.33,;-3.33,-1.55,;-4.64,-2.31,;-.65,-1.56,;.68,-2.33,;.68,-3.87,;2.01,-4.64,;3.36,-3.86,;4.81,-4.34,;4.83,-5.88,;6.16,-6.65,;6.16,-8.17,;7.49,-8.94,;8.82,-8.17,;10.16,-8.94,;11.49,-8.17,;11.49,-6.61,;10.13,-5.86,;8.82,-6.63,;7.47,-5.86,;12.81,-5.83,;12.79,-4.29,;14.15,-6.59,;5.72,-3.09,;7.26,-3.09,;4.81,-1.84,;3.36,-2.32,;2.01,-1.55,;2.01,-.01,;3.34,.76,;.68,.75,)|
Structure
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