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Reaction Details
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TargetCoagulation factor X
LigandBDBM50112516
Substrate/Competitorn/a
Meas. Tech.ChEBML_49327
Ki 0.200000±n/a nM
Citation Shaw, KJGuilford, WJGriedel, BDSakata, STrinh, LWu, SXu, WZhao, ZMorrissey, MM Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity. Bioorg Med Chem Lett12:1311-4 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50112516
NameBDBM50112516
Synonyms:7-{5-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-2-isopropyl-4-nitro-benzoimidazol-1-ylmethyl}-naphthalene-2-carboxamidine | CHEMBL283293
TypeSmall organic molecule
Emp. Form.C29H33N7O3
Mol. Mass.527.6174
SMILESn/a
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a